Physiology & Pharmacology
Fereshteh Iranmanesh; Amir Mousaei Amin; Amir Rahnama; Aliakbar Malaki Rad; Ali Shmasizadeh
Volume 24, Issue 3 , July and August 2017, , Pages 149-156
Abstract
Background & Objectives: The etiology of some liver diseases is unknown, but oxidative stress has an important role in liver pathogenesis. Pistachio (Pistacia Vera) has compounds with known antioxidant properties, including coenzyme 10, vitamin E and beta-carotene. This study designed to evaluate ...
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Background & Objectives: The etiology of some liver diseases is unknown, but oxidative stress has an important role in liver pathogenesis. Pistachio (Pistacia Vera) has compounds with known antioxidant properties, including coenzyme 10, vitamin E and beta-carotene. This study designed to evaluate protective effect of hydro-alcoholic extract of Pistacia Vera on liver enzymes following induction of hepatotoxicity.
Materials & methods: In this experimental study 40 male rats (200-250 g) were divided into five experimental groups. Carbon tetrachloride (CCl4) was used to induce hepatic toxicity. In normal group, no intervention was done. Vehicle group received intraperitoneal injection of 50% CCl4. Treatment groups were gavaged by three doses of Pistacia Vera hydro-alcoholic extract (10, 50 and 100 mg/kg) for 1 month. Plasma activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total blood protein, plasma concentration of high density lipoprotein (HDL) and low density lipoprotein (LDL) were measured.
Results: Gavage of different doses of pistachio extract in rats poisoned by CCl4 leads to decrease in plasma activity of AST and ALT and also the plasma concentration of LDL, while the plasma activity of ALP and plasma concentration of total protein and HDL were not changed in these animals.
Conclusion: Result of this study demonstrated that chronic gavage of pistachio hydro-alcoholic extract could decrease hepatotoxicity induced by CCl4. More investigation is needed for possible clinical usage of pistachio on liver insufficiency.
Mojtaba Akramian Fard; Amir Moghaddam Ahmadi; Fatemeh Ayyobi; Hasan Nakisa; Zahra Hadadian; Mohammad Shabani; Mohammadollah Tavakoli; Ali Shamsi zadeh
Volume 22, Issue 1 , March and April 2015, , Pages 36-44
Abstract
Background: Oxidative stresses have some role in neuronal pathogenesis in Substantia nigra and induction of Parkinson's disease. It has been reported that Achillea millefolium has antioxidant and nuoropropective effects. In this study, we investigated the effects of Aqueous extract of Achillea millefolium ...
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Background: Oxidative stresses have some role in neuronal pathogenesis in Substantia nigra and induction of Parkinson's disease. It has been reported that Achillea millefolium has antioxidant and nuoropropective effects. In this study, we investigated the effects of Aqueous extract of Achillea millefolium in a Parkinson’s diseases model induced by ICV injection of 6-hydroxydopamin in male rats.
Materials and Methods: In this experimental study, 60 male rats were allocated into 6 groups including Control, Parkinson’s and Parkinson’s groups which treated by different doses of extract. Parkinson’s was induced by i.c.v injection of 6-OHDA. Aqueous extract of Achillea millefolium (1.4 and 2.8 mg/kg) was gavaged by two ways including repeated gavage (14 days before and for 14 days after 6-OHDA injection) and acute gavage (once in day 13 after 6-OHDA injection). Parkinson’s was evaluated using Rotarod and Wire grasping tests on day 14 after 6-OHDA injection.
Results: The result of this study demonstrated that repeated gavage of Achillea millefolium extract improved motility and muscle tone following administration of 6-OHDA in rats (p
Ahmad Taghavi Rafsanjani; SeyyedAli Haeri Rohani; Aliasghar Porshanazari; Ali Shamsizadeh; Mohammad Allah Tavakkoli
Volume 20, Issue 3 , September and October 2013, , Pages 347-358
Abstract
Background and purpose: Morphine addiction and morphine withdrawal syndrome are of main problems in human societies. In the present study, effect of nicotine on the strength of physical and psychological dependency, produced by single and repeated doses of morphine, was investigated.
Material and method: ...
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Background and purpose: Morphine addiction and morphine withdrawal syndrome are of main problems in human societies. In the present study, effect of nicotine on the strength of physical and psychological dependency, produced by single and repeated doses of morphine, was investigated.
Material and method: Male wistar rats were dependent to morphine with single and repeated dose protocols. In the single dose protocol, rats received only one dose of morphine and 24h later were given Naloxone. In the repeated dose protocol, rats received incremental doses of morphine for 7 days and 24h after the last dose (8th day) were given Naloxone. In the single dose protocol, rats were given one dose of nicotine 30 min before Naloxone. However in the repeated doses they received nicotine 15 min before morphine for 4 days from 4th day to 7th day. 5 min after Naloxone each rat′s behavior was captured for 30 min. then physical and psychological signs of withdrawal syndrome were recorded.
Results: Results showed that injection of repeated and even single dose of morphine can produce dependency. Nicotine consumption attenuated strength of withdrawal syndrome signs, specially increasing weight excrement and total withdrawal score in single dose protocol and weight excrement increasing, weight decreasing, place aversion, and total withdrawal score in repeated dose treatment.
Conclusion: Based on our data, even a single dose of morphine can produce dependency in rats. Conversely, Nicotine consumption attenuates strength of withdrawal syndrome signs.
Ali Shmasi zadeh; GholamHossein Hasanshahi; Ali Rohbakhsh; Fatemeh Ayobi; Mahshid Tahmtan
Volume 19, Issue 4 , January and February 2013, , Pages 310-324
Abstract
Background: Transient global cerebral ischemia, which leads to the extensive neuronal damage in the brain, results in a deficit in learning and memory. We designed the present study to investigate the effect of exercise preconditioning on learning and spatial memory following transient cerebral ischemia ...
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Background: Transient global cerebral ischemia, which leads to the extensive neuronal damage in the brain, results in a deficit in learning and memory. We designed the present study to investigate the effect of exercise preconditioning on learning and spatial memory following transient cerebral ischemia in rat. Materials and methods: In this experimental study, 50 male wistar rats weighing 250-300g were randomly allocated into different groups. Exercise was done by treadmill and for inducing cerebral ischemia both common carotid arteries were occluded for 10 minutes. Memory was evaluated by use of a step-through passive avoidance task. Sensory motor deficites was assesed by adhesive removal test and for evaluating slip ratio we used ledge beam walking test. Reslults: One week after transient cerebral ischemia, response latency decreased in passive avoidance test. Also touch time, remove time and slip ratio were increased in these animals. Exercise preconditioning improved the measured indices in ischemic rats. Conclusion: Exercise preconditioning improved deficites in learning and memory and also sensory motor function following transient cerebral ischemia.
Mohammad Kazemi Arababadi; GhloamHossein Hasanshahi; Narges Yaghini; Reza Nosratabadi; Vahid Pooladvand; Ali Shamsizadeh
Volume 17, Issue 1 , March and April 2010, , Pages 33-38
Abstract
Background and Purpose: Cytokines are among the many immune system factors involved in diabetes pathogenesis. The level of cytokines expression such as IFN-y is varying in individuals and societies. Due to the fact that diabetes nephropathies are known as inflammatory disorders and the role of cytokines ...
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Background and Purpose: Cytokines are among the many immune system factors involved in diabetes pathogenesis. The level of cytokines expression such as IFN-y is varying in individuals and societies. Due to the fact that diabetes nephropathies are known as inflammatory disorders and the role of cytokines especially IFN-g in the establishment of inflammations is well understood, the present study was aimed to examine serum level of IFN-y in type 2 diabetes patients with nephropathy complications. Material and methods: In this cross sectional descriptive study, serum samples were obtained from 100 type 2 diabetes patients with nephropathy and 100 healthy controls for the analysis of IFN-g serum level (eBiosense, ESP). Consent forms were also filled out by patients and healthy controls according to the rules and regulations of Zahedan Islamic Azad University Ethical Committee. The obtained data and questionnaires were analyzed in SPSS using ANOVA; p